I decided to do a dumb thing: I'm going to run OS X 10.8 Mountain Lion on my main machine to see how well it holds up.
I was having a few issues with Lion, and figured it was time to wipe anyway and reinstall. Since we have access to the Developer's preview, I thought "What the heck?" and loaded it up.
Install went smoothly, and most applications are working as expected. The only one that isn't working right is Apple Remote Desktop, but that doesn't really surprise me: Lion didn't work right with ARD for some time.
It's three days in, and so far, not too bad. We'll see as time goes on.